Ebola Virus Disease (EVD) prevention and control has succeeded in the context of a well-functioning surveillance system within a broader national health system. This includes adequate staff, well equipped laboratories, resources (e.g personal protective equipment) and staff commitment. In Africa, the countries have many challenges regarding disease surveillance and response such as underqualified staff, cultural beliefs and sometimes, lack of trust for formal health care sector performance. This has increases the impact of endemic diseases and their associated deaths. The way forward includes adequate resources provision and training for health workers especially laboratory staff need.